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Molecular detection of chloroquine resistance in Plasmodium vivax isolates from North India: Analysis of single nucleotide polymorphisms in pvmdr1 gene.

Molecular and biochemical parasitology - 1 Jun 2026

Nityadarshini Neha, Bir Raunak, Biswas Jaya, Jadon Ranveer Singh, Mirdha Bijay Ranjan, Verma Nishant

Abstract excerpt

OBJECTIVES: Plasmodium vivax remains a major cause of malaria in India, with chloroquine still used as first-line therapy. However, molecular data on resistance markers are limited. This study aimed to detect mutations in the pvmdr1 gene of P. vivax isolates and to assess their potential role as markers of chloroquine resistance. METHODS: A total of 7530 patients with acute undifferentiated febrile illness were...

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PMID: 42034171
DOI: 10.1016/j.molbiopara.2026.111743

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