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Article

Stable and efficient cassette exchange under non-selectable conditions by combined use of two site-specific recombinases.

Nucleic acids research - 1 Nov 2002

Lauth Matthias, Spreafico Fabio, Dethleffsen Kathrin, Meyer Michael

Abstract excerpt

Work of the last decade has proven the 'one gene- one product-one function' hypothesis an oversimplification. To further unravel the emerging 'one gene-multiple products-even more functions' concept, new methods (such as subtle knock-in and tightly regulated conditional mutations) for the analysis of gene function in health and disease are required. Another class of improvements (such as tetraploid fusion and...

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Identifiers

PMID: 12409474
DOI: 10.1093/nar/gnf114
PMCID: PMC135837

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