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Article

Constitutive and conditional RNAi transgenesis in mice.

Methods (San Diego, Calif.) - 1 Apr 2011

Kleinhammer Aljoscha, Wurst Wolfgang, Kühn Ralf

Abstract excerpt

Gene silencing by RNA interference (RNAi) has become a routine method for extracting function from the mammalian genome. Short hairpin (sh) RNAs expressed from stably integrated vectors mediate RNAi both in cultured cells and mice and present therefore a fast alternative to conventional knockout approaches. We describe three strategies to control gene silencing in mice by shRNA expression that can be applied to...

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PMID: 21184828
DOI: 10.1016/j.ymeth.2010.12.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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