Article
High throughput gene trapping and postinsertional modifications of gene trap alleles.
Methods (San Diego, Calif.) - 1 Apr 2011
Schnütgen Frank, Ehrmann Franziska, Ruiz-Noppinger Patricia, von Melchner Harald
Abstract excerpt
Gene trapping is a high-throughput insertional mutagenesis approach that has been primarily used in mouse embryonic stem cells (ESCs). As a high throughput technology, gene trapping helped to generate tenth of thousands of ESC lines harboring mutations in single genes that can be used for making knock-out mice. Ongoing international efforts operating under the umbrella of the International Knockout Mouse...
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