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Article

Class A Plexins Are Organized as Preformed Inactive Dimers on the Cell Surface.

Biophysical journal - 3 Nov 2015

Marita Morgan, Wang Yuxiao, Kaliszewski Megan J, Skinner Kevin C, Comar William D, Shi Xiaojun, Dasari Pranathi, Zhang Xuewu, Smith Adam W

Abstract excerpt

Plexins are single-pass transmembrane receptors that bind the axon guidance molecules semaphorins. Single-pass transmembrane proteins are an important class of receptors that display a wide variety of activation mechanisms, often involving ligand-dependent dimerization or conformational changes. Resolving the activation mechanism and dimerization state of these receptors is extremely challenging, especially in a...

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Identifiers

PMID: 26536270
DOI: 10.1016/j.bpj.2015.04.043
PMCID: PMC4643210

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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