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Article

Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors.

Neuron - 5 Oct 2016

Levitz Joshua, Habrian Chris, Bharill Shashank, Fu Zhu, Vafabakhsh Reza, Isacoff Ehud Y

Abstract excerpt

G protein-coupled receptors (GPCRs) mediate cellular responses to a wide variety of extracellular stimuli. GPCR dimerization may expand signaling diversity and tune functionality, but little is known about the mechanisms of subunit assembly and interaction or the signaling properties of heteromers. Using single-molecule subunit counting on class C metabotropic glutamate receptors (mGluRs), we map dimerization...

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Identifiers

PMID: 27641494
DOI: 10.1016/j.neuron.2016.08.036
PMCID: PMC5053906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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