Article
Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors.
Neuron - 5 Oct 2016
Levitz Joshua, Habrian Chris, Bharill Shashank, Fu Zhu, Vafabakhsh Reza, Isacoff Ehud Y
Abstract excerpt
G protein-coupled receptors (GPCRs) mediate cellular responses to a wide variety of extracellular stimuli. GPCR dimerization may expand signaling diversity and tune functionality, but little is known about the mechanisms of subunit assembly and interaction or the signaling properties of heteromer...
Topics
- Animals
- Cells, Cultured
- Excitatory Amino Acid Agonists
- Humans
- Membrane Potentials
- Mutation
- Oocytes
- Protein Interaction Domains and Motifs
- Protein Multimerization
- Protein Structure, Quaternary
- Protein Subunits
- Rats
- Receptors, Metabotropic Glutamate
- Xenopus