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Article

Trans-dimerization of JAM-A regulates Rap2 and is mediated by a domain that is distinct from the cis-dimerization interface.

Molecular biology of the cell - 1 May 2014

Monteiro Ana C, Luissint Anny-Claude, Sumagin Ronen, Lai Caroline, Vielmuth Franziska, Wolf Mattie F, Laur Oskar, Reiss Kerstin, Spindler Volker, Stehle Thilo, Dermody Terence S, Nusrat Asma, Parkos Charles A

Abstract excerpt

Junctional adhesion molecule-A (JAM-A) is a tight junction-associated signaling protein that regulates epithelial cell proliferation, migration, and barrier function. JAM-A dimerization on a common cell surface (in cis) has been shown to regulate cell migration, and evidence suggests that JAM-A may form homodimers between cells (in trans). Indeed, transfection experiments revealed accumulation of JAM-A at sites...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24672055
DOI: 10.1091/mbc.E14-01-0018
PMCID: PMC4019489

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