Article
Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors.
Nature chemical biology - 1 Sept 2020
Möller Jan, Isbilir Ali, Sungkaworn Titiwat, Osberg Brendan, Karathanasis Christos, Sunkara Vikram, Grushevskyi Eugene O, Bock Andreas, Annibale Paolo, Heilemann Mike, Schütte Christof, Lohse Martin J
Abstract excerpt
G-protein-coupled receptors (GPCRs) are key signaling proteins that mostly function as monomers, but for several receptors constitutive dimer formation has been described and in some cases is essential for function. Using single-molecule microscopy combined with super-resolution techniques on intact cells, we describe here a dynamic monomer-dimer equilibrium of µ-opioid receptors (µORs), where dimer formation is...
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