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Article

Heroin-induced suppression of saccharin intake in OPRM1 A118G mice.

Brain research bulletin - 1 Apr 2018

Freet Christopher S, Alexander Danielle N, Imperio Caesar G, Ruiz-Velasco Victor, Grigson Patricia S

Abstract excerpt

The single nucleotide polymorphism of the μ-opioid receptor, OPRM1 A118G, has been associated with greater drug and alcohol use, increased sensitivity to pain, and reduced sensitivity to the antinociceptive effects of opiates. In the present studies, we employed a 'humanized' mouse model containing the wild-type (118AA) or variant (118GG) allele to examine behavior in a model of heroin-induced devaluation of an...

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Identifiers

PMID: 28939474
DOI: 10.1016/j.brainresbull.2017.09.008
PMCID: PMC5860935

Genes

OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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