Article
Cocaine-induced suppression of saccharin intake and morphine modulation of Ca²⁺ channel currents in sensory neurons of OPRM1 A118G mice.
Physiology & behavior - 1 Feb 2015
Freet Christopher S, Ballard Sarah M, Alexander Danielle N, Cox Taylor A, Imperio Caesar G, Anosike Nnaemeka, Carter Alyssa B, Mahmoud Saifeldin, Ruiz-Velasco Victor, Grigson Patricia S
Abstract excerpt
Several studies have shown that human carriers of the single nucleotide polymorphism of the μ-opioid receptor, OPRM1 A118G, exhibit greater drug and alcohol use, increased sensitivity to pain, and reduced sensitivity to the antinociceptive effects of opiates. In the present study, we employed a 'humanized' mouse model containing the wild-type (118AA) or variant (118GG) allele to examine behavior in our model of...
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