Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apparent behavioral benefits of tau overexpression in P301L tau transgenic mice.

Journal of Alzheimer's disease : JAD - 1 Dec 2008

Morgan Dave, Munireddy Sanjay, Alamed Jennifer, DeLeon Jason, Diamond David M, Bickford Paula, Hutton Michael, Lewis Jada, McGowan Eileen, Gordon Marcia N

Abstract excerpt

Transgenic mice expressing human tau containing the P301L tau mutation (JNPL3; tau mice) develop motor neuron loss, paralysis and death between 7 and 12 months. Surprisingly, at 5 and 7 months of age, tau transgenic mice were superior to other genotypes in the rotarod task, and had near perfect scores on the balance beam and coat hanger tests. One tau transgenic mouse was performing at a superior level in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cognition Disorders
Share to Maze Learning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neurodegenerative Diseases

Share to Postural Balance

Share to Psychomotor Performance

Share to Retinal Degeneration

Share to Spinal Cord

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19096159
DOI: 10.3233/jad-2008-15407
PMCID: PMC3018352

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apparent behavioral benefits of tau overexpression in P301L tau transgenic mice.PMID 19096159Read ↗

Characterization of a novel transgenic rat carrying human tau with mutation P301L.Semantic proximity Read ↗

Early-onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice.Semantic proximity Read ↗

Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)Semantic proximity Read ↗

Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits.Semantic proximity Read ↗

Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation.Semantic proximity Read ↗

Progressive Motor Deficit is Mediated by the Denervation of Neuromuscular Junctions and Axonal Degeneration in Transgenic Mice Expressing Mutant (P301S) Tau Protein.Semantic proximity Read ↗

Early Cognitive/Social Deficits and Late Motor Phenotype in Conditional Wild-Type TDP-43 Transgenic MiceSemantic proximity Read ↗

Novel Behavioural Characteristics of Male Human P301S Mutant Tau Transgenic Mice – A Model for TauopathySemantic proximity Read ↗

The retinal degeneration (rd) gene seriously impairs spatial cognitive performance in normal and Alzheimer’s transgenic miceSemantic proximity Read ↗

Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia.Semantic proximity Read ↗

Early behavioural markers of disease in P301S tau transgenic mice.Semantic proximity Read ↗

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.