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Article

Alpha-synuclein transgenic mice exhibit reduced anxiety-like behaviour.

Experimental neurology - 1 Apr 2008

George Sonia, van den Buuse Maarten, San Mok Su, Masters Colin L, Li Qiao-Xin, Culvenor Janetta G

Abstract excerpt

Up to 40% of Parkinson's disease patients suffer from anxiety, but little is known about the mechanisms involved. We used the elevated plus maze and open field test to evaluate groups of young adult mice expressing different levels of alpha-synuclein, including mice transgenic for human alpha-synuclein with the A53T mutation. Compared to alpha-synuclein knock-out mice and wild-type controls, alpha-synuclein A53T...

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Identifiers

PMID: 18295208
DOI: 10.1016/j.expneurol.2007.12.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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