Article
[T-lymphocyte receptor genes: genome organization and genetic mechanisms of repertoire diversity].
Revue du rhumatisme (Ed. francaise : 1993) - 1 Jan 1994
Kay R A, Ollier W E
Abstract excerpt
The T-cell receptor (TCR) is fundamental to the immune process in both health and disease. Reviewed here is the genetic organisation of the gene complexes which encode the TCR polypeptide chains alpha, beta, gamma, and delta. The TCR is by necessity a diverse structure and we consider the genetic mechanisms responsible for this. These include multiple variable gene segment isotypes, somatic recombination of gene...
Topics
- Analysis of Variance
- Gene Rearrangement, T-Lymphocyte
- Genes
- Genetic Variation
- Humans
- Polymorphism, Genetic
- Receptors, Antigen, T-Cell