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Article

Tumor location, but not H3.3K27M, significantly influences the blood-brain-barrier permeability in a genetic mouse model of pediatric high-grade glioma.

Journal of neuro-oncology - 1 Jan 2016

Subashi Ergys, Cordero Francisco J, Halvorson Kyle G, Qi Yi, Nouls John C, Becher Oren J, Johnson G Allan

Abstract excerpt

Pediatric high-grade gliomas (pHGGs) occur with strikingly different frequencies in infratentorial and supratentorial regions. Although histologically these malignancies appear similar, they represent distinct diseases. Recent genomic studies have identified histone K27M H3.3/H3.1 mutations in the majority of brainstem pHGGs; these mutations are rarely encountered in pHGGs that arise in the cerebral cortex....

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Identifiers

PMID: 26511492
DOI: 10.1007/s11060-015-1969-9
PMCID: PMC4720569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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