Article
Advanced Pediatric Diffuse Pontine Glioma Animal Models Pave the Way Towards Precision Medicine
2021-01-18
Abstract excerpt
Diffuse intrinsic pontine gliomas (DIPGs) account for ~15% of pediatric brain tumors, which invariably present with poor survival regardless of treatment mode. Several seminal studies have revealed that 80% of DIPGs harbor H3K27M mutation coded by HIST1H3B, HIST1H3C and H3F3A genes. The H3K27M mutation has broad effects on gene expression and is considered a tumor driver. Determination of the effects of H3K27M on...
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Identifiers and source
- Literature Corpus work
- 75083cc7-365c-51ce-9f3e-c06da25cd6cc
- DOI
- 10.20944/preprints202101.0337.v1