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Article

Topographic correlates of driver mutations and endogenous gene expression in pediatric diffuse midline gliomas and hemispheric high-grade gliomas.

Scientific reports - 13 Jul 2021

Kazarian Eve, Marks Asher, Cui Jin, Darbinyan Armine, Tong Elizabeth, Mueller Sabine, Cha Soonmee, Aboian Mariam S

Abstract excerpt

We evaluate the topographic distribution of diffuse midline gliomas and hemispheric high-grade gliomas in children with respect to their normal gene expression patterns and pathologic driver mutation patterns. We identified 19 pediatric patients with diffuse midline or high-grade glioma with preoperative MRI from tumor board review. 7 of these had 500 gene panel mutation testing, 11 patients had 50 gene panel...

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Identifiers

PMID: 34257334
DOI: 10.1038/s41598-021-92943-0
PMCID: PMC8277861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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