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Advanced Pediatric Diffuse Pontine Glioma Murine Models Pave the Way towards Precision Medicine

5 Mar 2021

Abstract excerpt

Diffuse intrinsic pontine gliomas (DIPGs) account for ~15% of pediatric brain tumors, which invariably present with poor survival regardless of treatment mode. Several seminal studies have revealed that 80% of DIPGs harbor H3K27M mutation coded by HIST1H3B, HIST1H3C and H3F3A genes. The H3K27M mutation has broad effects on gene expression and is considered a tumor driver. Determination of the effects of H3K27M on...

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PMID: 33807733
DOI: 10.3390/cancers13051114

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