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Article

Evolving P450pyr Monooxygenase for Regio- and Stereoselective Hydroxylations.

Chimia - 1 Jan 2015

Yang Yi, Li Zhi

Abstract excerpt

P450pyr monooxygenase from Sphingomonas sp. HXN-200 catalysed the regio- and stereoselective hydroxylation at a non-activated carbon atom, a useful but challenging reaction in classic chemistry, with unique substrate specificity for a number of alicyclic compounds. New P450pyr mutants were developed by directed evolution with improved catalytic performance, thus significantly extending the application of the...

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Identifiers

PMID: 26507217
DOI: 10.2533/chimia.2015.136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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