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Article

Inverting the enantioselectivity of P450pyr monooxygenase by directed evolution.

Chemical communications (Cambridge, England) - 14 Aug 2010

Tang Weng Lin, Li Zhi, Zhao Huimin

Abstract excerpt

We report the first example of directed evolution of a P450 monooxygenase with inverted enantioselectivity for asymmetric biohydroxylation. The biohydroxylation product of the best mutant 1AF4A has an ee of 83% (R) compared to the wild type's ee of 43% (S).

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Source

Identifiers

PMID: 20520890
DOI: 10.1039/c0cc00735h

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20520890-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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