Article
P450(BM3) (CYP102A1): connecting the dots.
Chemical Society reviews - 7 Feb 2012
Whitehouse Christopher J C, Bell Stephen G, Wong Luet-Lok
Abstract excerpt
P450(BM3) (CYP102A1), a fatty acid hydroxylase from Bacillus megaterium, has been extensively studied over a period of almost forty years. The enzyme has been redesigned to catalyse the oxidation of non-natural substrates as diverse as pharmaceuticals, terpenes and gaseous alkanes using a variety of engineering strategies. Crystal structures have provided a basis for several of the catalytic effects brought about...
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