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Article

Enantioselective Benzylic Hydroxylation Catalysed by P450 Monooxygenases: Characterisation of a P450cam Mutant Library and Molecular Modelling.

Chembiochem : a European journal of chemical biology - 2 Mar 2016

Eichler Anja, Gricman Łukasz, Herter Susanne, Kelly Paul P, Turner Nicholas J, Pleiss Jürgen, Flitsch Sabine L

Abstract excerpt

Cytochrome P450 monooxygenases can catalyse the stereoselective C-H activation of a very broad range of substrates. Prediction and control of enantioselectivity of this enzyme class is of great interest for the synthesis of high-value chiral molecules. Here we have used a combination of molecular dynamics simulations and experimental screening to study the enantioselectivity of a library of active-site mutants of...

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PMID: 26698167
DOI: 10.1002/cbic.201500536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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