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Article

Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress

27 Oct 2015

Abstract excerpt

Exposure to extreme stress can trigger the development of major depressive disorder (MDD) as well as post-traumatic stress disorder (PTSD). The molecular mechanisms underlying the structural and functional alterations within corticolimbic brain regions, including the prefrontal cortex (PFC) and amygdala of individuals subjected to traumatic stress, remain unknown. In this study, we show that serum and...

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PMID: 26506154
DOI: 10.1371/journal.pbio.1002282

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