Article

Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility

2020-06-08

Abstract excerpt

<h4>Background</h4> Imbalance in prefrontal cortical (PFC) pyramidal neuron excitation:inhibition is thought to underlie symptomologies shared across stress-related disorders and neuropsychiatric disease, including dysregulation of emotion and cognitive function. G protein-gated inwardly rectifying K + (GIRK/Kir3) channels mediate excitability of medial PFC pyramidal neurons, however the functional role of these...

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Literature Corpus work: 8e41ee44-390d-5165-9080-7410fcd87d42
DOI: 10.1101/2020.06.08.139725

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Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibilityDOI 10.1101/2020.06.08.139725Read

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