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Article

Development of a novel analysis method for evaluating PTSD-like behavior in mice based on DSM-V criteria.

Stress (Amsterdam, Netherlands) - 31 Dec 2026

Holman Heather, Eggert Kaylee, Xiong Ying, Nietert Paul J, Sidles Sara J, Kelly Ryan R, LaRue Amanda C, Mulholland Patrick J, Rinker Jennifer A, Jones Jeffrey A

Abstract excerpt

Posttraumatic stress disorder (PTSD) occurs after exposure to a traumatic event, leading to debilitating symptoms, including avoidance, hypervigilance, and functional impairment. There is a paucity of effective therapies to treat PTSD, partially due to the difficulty in identifying consistent underlying mechanisms. Using a modified single prolonged stress (mSPS) paradigm combined with single housing to induce...

Topics

Animals
Stress Disorders, Post-Traumatic
Mice
Mice, Inbred C57BL
Diagnostic and Statistical Manual of Mental Disorders
Male
Behavior, Animal
Disease Models, Animal
Fear
Stress, Psychological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41518007
DOI: 10.1080/10253890.2025.2612332
PMCID: PMC13244265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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