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Article

Development of a novel analysis method for evaluating PTSD-like behavior in mice based on DSM-V criteria.

Stress (Amsterdam, Netherlands) - 31 Dec 2026

Holman Heather, Eggert Kaylee, Xiong Ying, Nietert Paul J, Sidles Sara J, Kelly Ryan R, LaRue Amanda C, Mulholland Patrick J, Rinker Jennifer A, Jones Jeffrey A

Abstract excerpt

Posttraumatic stress disorder (PTSD) occurs after exposure to a traumatic event, leading to debilitating symptoms, including avoidance, hypervigilance, and functional impairment. There is a paucity of effective therapies to treat PTSD, partially due to the difficulty in identifying consistent underlying mechanisms. Using a modified single prolonged stress (mSPS) paradigm combined with single housing to induce...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41518007
DOI: 10.1080/10253890.2025.2612332
PMCID: PMC13244265

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