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Article

Acute pretrauma ethanol exacerbates PTSD-like phenotype in rats and is reversed by early intranasal ketamine.

Scientific reports - 14 Jun 2026

Yogev Bar Eilat, Levi Gal, Efroni Noa, Sintov Amnon C, Todder Doron, Zohar Joseph, Cohen Hagit

Abstract excerpt

Alcohol consumption before trauma is a prevalent but understudied risk factor for posttraumatic stress disorder (PTSD). This study investigated whether acute ethanol exposure prior to trauma modulates PTSD-like symptom development in rats, identified hippocampal mechanisms involved, and tested an early post-trauma intervention. Adult male Sprague-Dawley rats received ethanol (1.6 g/kg, 40% v/v, intraperitoneal)...

Read the complete abstract on PubMed

Topics

Animals
Stress Disorders, Post-Traumatic
Ketamine
Ethanol
Male
Rats
Rats, Sprague-Dawley

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Neuropeptide Y

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

Administration, Intranasal

Disease Models, Animal

Hippocampus

Phenotype

Potassium Channels

Brain-Derived Neurotrophic Factor

CA1 Region, Hippocampal

Source

Open in PubMed Open full text

Identifiers

PMID: 42289471
DOI: 10.1038/s41598-026-56757-2
PMCID: PMC13527053

Genes

NPY
HCN1
BDNF
CA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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