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Article

Ribosomal protein S6 kinase 1 signaling in prefrontal cortex controls depressive behavior.

Proceedings of the National Academy of Sciences of the United States of America - 12 May 2015

Dwyer Jason M, Maldonado-Avilés Jaime G, Lepack Ashley E, DiLeone Ralph J, Duman Ronald S

Abstract excerpt

Current treatments for major depressive disorder (MDD) have a time lag and are ineffective for a large number of patients. Development of novel pharmacological therapies requires a comprehensive understanding of the molecular events that contribute to MDD pathophysiology. Recent evidence points toward aberrant activity of synaptic proteins as a critical contributing factor. In the present studies, we used...

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Identifiers

PMID: 25918363
DOI: 10.1073/pnas.1505289112
PMCID: PMC4434715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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