Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

miR-138 Increases Depressive-Like Behaviors by Targeting SIRT1 in Hippocampus

1 Apr 2020

Abstract excerpt

BACKGROUND: Major depressive disorder (MDD) is a serious and common mood disorder with unknown etiology. Emerging evidence has demonstrated the critical roles of SIRT1 and microRNAs (miRNAs) in the progression of MDD. However, the underlying molecular mechanisms remain to be fully understood. METHODS: In the present study, the expression level of miR-138 and SIRT1 were analyzed by RT-PCR or Western blotting in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to MicroRNA in disease regulation
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32308399
DOI: 10.2147/ndt.s237558

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

miR-138 Increases Depressive-Like Behaviors by Targeting SIRT1 in HippocampusPMID 32308399Read ↗

Molecular mechanism of reward treatment ameliorating chronic stress-induced depressive-like behavior assessed by sequencing miRNA and mRNA in medial prefrontal cortexSemantic proximity Read ↗

Role of the Sirt6/Hmgb1 pathway in neuroinflammation of Sleep deprivation-induced depressed miceSemantic proximity Read ↗

Hippocampal Sirtuin 1 Signaling Mediates Depression-like BehaviorSemantic proximity Read ↗

MiR-155 is involved in major depression disorder and antidepressant treatment via targeting SIRT1Semantic proximity Read ↗

SIRT2 is involved in the modulation of depressive behaviors.Semantic proximity Read ↗

Therapeutic role of long non-coding RNA TCONS_00019174 in depressive disorders is dependent on Wnt/β-catenin signaling pathwaySemantic proximity Read ↗

Oroxylum indicum Seed Extract as a Potential Antidepressant in Chronic Stress Mouse Model of DepressionSemantic proximity Read ↗

Resveratrol improves learning and memory in normally aged mice through microRNA-CREB pathwaySemantic proximity Read ↗

SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic MechanismsSemantic proximity Read ↗

Modelling the polygenicity and clinical heterogeneity of human depression in mice to identify biomarkers predictive of treatment responseSemantic proximity Read ↗

MicroRNA Let-7e in the Mouse Prefrontal Cortex Differentiates Restraint-Stress-Resilient Genotypes from Susceptible Genotype.Semantic proximity Read ↗

MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a Genetic Model of Depression and Targets the Glutamate Transporter SLC1A1 (EAAT3) in Vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.