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Article

Chronic stress and impaired glutamate function elicit a depressive-like phenotype and common changes in gene expression in the mouse frontal cortex.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jan 2011

Tordera R M, Garcia-García A L, Elizalde N, Segura V, Aso E, Venzala E, Ramírez M J, Del Rio J

Abstract excerpt

Major depression might originate from both environmental and genetic risk factors. The environmental chronic mild stress (CMS) model mimics some environmental factors contributing to human depression and induces anhedonia and helplessness. Mice heterozygous for the synaptic vesicle protein (SVP) vesicular glutamate transporter 1 (VGLUT1) have been proposed as a genetic model of deficient glutamate function linked...

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PMID: 20937555
DOI: 10.1016/j.euroneuro.2010.06.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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