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Article

Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron-sulfur protein.

Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 2015

Jafari Gholamali, Wasko Brian M, Tonge Ashley, Schurman Nathan, Dong Cindy, Li Zhongyu, Peters Rebecca, Kayser Ernst-Bernhard, Pitt Jason N, Morgan Phil G, Sedensky Margaret M, Crofts Antony R, Kaeberlein Matt

Abstract excerpt

Mitochondria play an important role in numerous diseases as well as normative aging. Severe reduction in mitochondrial function contributes to childhood disorders such as Leigh Syndrome, whereas mild disruption can extend the lifespan of model organisms. The Caenorhabditis elegans isp-1 gene encodes the Rieske iron-sulfur protein subunit of cytochrome c oxidoreductase (complex III of the electron transport...

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PMID: 26504246
DOI: 10.1073/pnas.1509416112
PMCID: PMC4653183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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