Article

High-throughput behavioural phenotyping of 25 <i>C. elegans</i> disease models including patient-specific mutations

2025-02-08

Abstract excerpt

Genetic diagnosis is fast and cheap, challenging our capacity to evaluate the functional impact of novel disease-causing variants or identify potential therapeutics. Model organisms including C. elegans present the possibility of systematically modelling genetic diseases, yet robust, high-throughput methods have been lacking. Here we show that automated multi-dimensional behaviour tracking can detect phenotypes i...

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Literature Corpus work: 177cbfb5-6f89-5c18-86ad-950da9fab6dd
DOI: 10.1101/2025.02.07.637026

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