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Article

Exploring age-related iron dysregulation: effects on longevity, body size, and behavior in C. elegans.

Experimental gerontology - 1 Sept 2025

Zeidan Rola S, Ebea-Ugwuanyi Pearl, Sykes Shannon, Evripidou Natalia, Pan Evelyn, Markovich Zachary, Sheng Yi, Han Sung Min, Leeuwenburgh Christiaan, Xiao Rui

Abstract excerpt

Age-related iron accumulation is widely observed in various species and significantly impacts physiological processes. However, systematic investigation into how age-related iron dysregulation affects different life traits is still limited. This study utilizes the model organism C. elegans to examine the roles of iron regulatory genes throughout different life stages, focusing on their effects on iron...

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Identifiers

PMID: 40617521
DOI: 10.1016/j.exger.2025.112826
PMCID: PMC13162325

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