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Article

Pivotal role of miR-448 in the development of ROS-induced cardiomyopathy.

Cardiovascular research - 1 Dec 2015

Kyrychenko Sergii, Kyrychenko Viktoriia, Badr Myriam A, Ikeda Yoshiyuki, Sadoshima Junichi, Shirokova Natalia

Abstract excerpt

AIMS: Nicotinamide adenine dinucleotide oxidases (NOXs) are important contributors to cellular oxidative stress in the cardiovascular system. The NOX2 isoform is upregulated in numerous disorders, including dystrophic cardiomyopathy, where it drives the progression of the disease. However, mechanisms underlying NOX2 overexpression are still unknown. We investigated the role of microRNAs (miRs) in the regulation...

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Share to Arrhythmias, Cardiac
Share to Calcium Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiomyopathy, Dilated

Share to Mice, Inbred mdx

Share to Muscular Dystrophy, Duchenne

Share to NADPH Oxidase 2

Share to NADPH Oxidases

Share to Ventricular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 26503985
DOI: 10.1093/cvr/cvv238
PMCID: PMC4648202

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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