Article

Human iPSC-Based Model Reveals NOX4 as Therapeutic Target in Duchenne Cardiomyopathy

2021-09-13

Abstract excerpt

<h4>ABSTRACT</h4> Duchenne muscular dystrophy (DMD) is an X-linked progressive muscle disorder, caused by mutations in the Dystrophin gene. Cardiomyopathy is one of the major causes of early death. In this study, we used DMD patient-specific induced pluripotent stem cells (iPSCs) to model cardiomyopathic features in DMD and unravel novel pathological mechanistic insights. Cardiomyocytes (CMs) differentiated from...

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Literature Corpus work: 2ea63a83-b00e-549d-a488-c5e0912cec40
DOI: 10.1101/2021.09.13.460090

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