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Perturbation of NCOA6 Leads to Dilated Cardiomyopathy

1 Aug 2014

Abstract excerpt

Dilated cardiomyopathy (DCM) is a progressive heart disease characterized by left ventricular dilation and contractile dysfunction. Although many candidate genes have been identified with mouse models, few of them have been shown to be associated with DCM in humans. Germline depletion of Ncoa6, a nuclear hormone receptor coactivator, leads to embryonic lethality and heart defects. However, it is unclear whether...

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PMID: 25131203
DOI: 10.1016/j.celrep.2014.07.027

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