Article
Inhibition of miR-208b improves cardiac function in titin-based dilated cardiomyopathy.
International journal of cardiology - 1 Mar 2017
Zhou Qifeng, Schötterl Sonja, Backes Daniel, Brunner Eva, Hahn Julia Kelley, Ionesi Elena, Aidery Parwez, Sticht Carsten, Labeit Siegfried, Kandolf Reinhard, Gawaz Meinrad, Gramlich Michael
Abstract excerpt
BACKGROUND: Dilated cardiomyopathy (DCM) is the result of maladaptive cardiac remodeling, which involves microRNA regulation. In turn, microRNAs can contribute to the remodeling process by post-transcriptional modulation of gene expression networks. The exact role of microRNAs in the pathogenesis of DCM is largely unknown. Here, we used an inducible DCM mouse model that carries a human truncation mutation in the...
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