Article

NOX4 inhibition promotes the remodeling of dystrophic muscle

2022-01-10

Abstract excerpt

<h4>ABSTRACT</h4> The muscular dystrophies (MDs) are genetic muscle diseases that result in progressive muscle degeneration followed by the fibrotic replacement of affected muscles as regenerative processes fail. Therapeutics that specifically address the fibrosis and failed regeneration associated with MDs represent a major unmet clinical need for MD patients, particularly those with advanced stage disease progr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 65afc4a2-60aa-53f8-8ebc-542b37919d3c
DOI: 10.1101/2022.01.08.475493

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NOX4 inhibition promotes the remodeling of dystrophic muscleDOI 10.1101/2022.01.08.475493Read

Skeletal muscle Nox4 knockout prevents and Nox2 knockout blunts loss of maximal diaphragm force in mice with heart failure with reduced ejection fractionSemantic proximity Read

Silencing Nfix rescues muscular dystrophy by delaying muscle regenerationSemantic proximity Read

The Interplay of Mitophagy and Inflammation in Duchenne Muscular DystrophySemantic proximity Read

Human iPSC-Based Model Reveals NOX4 as Therapeutic Target in Duchenne CardiomyopathySemantic proximity Read

Duchenne muscular dystrophy: pathogenesis and promising therapies.Semantic proximity Read

Pivotal role of miR-448 in the development of ROS-induced cardiomyopathy.Semantic proximity Read

The skeletal muscle phenotype of the DE50-MD dog model of Duchenne muscular dystrophySemantic proximity Read

Compartment-specific remodeling of skeletal muscle in Duchenne muscular dystrophySemantic proximity Read

NADPH oxidase 4 is dispensable for skin myofibroblast differentiation and wound healingSemantic proximity Read

Mitochondrial dysfunction is an early consequence of partial or complete dystrophin loss in mdx mice.Semantic proximity Read

Targeting Fibrosis in Duchenne Muscular DystrophySemantic proximity Read

Histological Methods to Assess Skeletal Muscle Degeneration and Regeneration in Duchenne Muscular DystrophySemantic proximity Read