Article

Skeletal muscle Nox4 knockout prevents and Nox2 knockout blunts loss of maximal diaphragm force in mice with heart failure with reduced ejection fraction

2022-05-29

Abstract excerpt

Patients with heart failure with reduced ejection fraction (HFrEF) experience diaphragm weakness that contributes to the primary disease symptoms of fatigue, dyspnea, and exercise intolerance. Weakness in the diaphragm is related to excessive production of reactive oxygen species (ROS), but the exact source of ROS remains unknown. NAD(P)H Oxidases (Nox), particularly the Nox2 and 4 isoforms, are important sources...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8b9c70a9-90a9-5394-a679-fa4918c7871f
DOI: 10.1101/2022.05.27.493689

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Skeletal muscle Nox4 knockout prevents and Nox2 knockout blunts loss of maximal diaphragm force in mice with heart failure with reduced ejection fractionDOI 10.1101/2022.05.27.493689Read

NOX4 inhibition promotes the remodeling of dystrophic muscleSemantic proximity Read

Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes.Semantic proximity Read

Pivotal role of miR-448 in the development of ROS-induced cardiomyopathy.Semantic proximity Read

Hypoxia Resistance Is an Inherent Phenotype of the Mouse Flexor Digitorum Brevis Skeletal Muscle.Semantic proximity Read

Antioxidants improve the phenotypes of dilated cardiomyopathy and muscle fatigue in mitochondrial superoxide dismutase-deficient mice.Semantic proximity Read

Aerobic exercise partially improves the skeletal muscle phenotype in a model of heart failure with preserved ejection fraction in male mice.Semantic proximity Read

Heart specific knockout of Ndufs4 ameliorates ischemia reperfusion injury.Semantic proximity Read

Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium.Semantic proximity Read

Nox5 and the Regulation of Cellular FunctionSemantic proximity Read

Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exerciseSemantic proximity Read

Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.Semantic proximity Read

Alternative Splicing of NOX4 in the Failing Human HeartSemantic proximity Read