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Article

Dopaminergic genetic variation moderates the effect of nicotine on cigarette reward.

Psychopharmacology - 1 Jan 2016

Harrell Paul T, Lin Hui-Yi, Park Jong Y, Blank Melissa D, Drobes David J, Evans David E

Abstract excerpt

RATIONALE: Cigarette smoking is influenced by nicotine’s effects on dopaminergic activity in the mesocorticolimbic pathway. This activity appears to be moderated by genetic variation, specifically a variable number tandem repeat (VNTR) polymorphism in the third exon of the dopamine receptor gene (DRD4). OBJECTIVE: We examined whether this polymorphism along with three DRD4 single-nucleotide polymorphisms (SNPs:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Dopamine D4

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Source

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Identifiers

PMID: 26497691
DOI: 10.1007/s00213-015-4116-6
PMCID: PMC5808950

Genes

DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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