Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A functional polymorphism, rs6280, in DRD3 is significantly associated with nicotine dependence in European-American smokers.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Oct 2008

Huang Weihua, Payne Thomas J, Ma Jennie Z, Li Ming D

Abstract excerpt

Nicotine enhances reward functions in the mesocorticolimbic dopamine system in general and the nucleus accumbens in particular. The genes encoding dopamine receptors are thus plausible candidates for involvement in nicotine dependence (ND). We investigated 13 single nucleotide polymorphisms (SNPs) spanning a region of the dopamine D(3) receptor gene (DRD3) to determine whether DRD3 is associated with ND. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to Family Health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation, Missense

Share to Receptors, Dopamine D3

Share to Smoking

Share to Tobacco Use Disorder

Share to United States

Share to White People

Source

Identifiers

PMID: 18348205
DOI: 10.1002/ajmg.b.30731

Genes

DRD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A functional polymorphism, rs6280, in DRD3 is significantly associated with nicotine dependence in European-American smokers.PMID 18348205Read ↗

Significant association of DRD1 with nicotine dependence.Semantic proximity Read ↗

Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence.Semantic proximity Read ↗

Dopamine receptor genes (DRD2, DRD3 and DRD4) and gene-gene interactions associated with smoking-related behaviors.Semantic proximity Read ↗

Significant association of glutamate receptor, ionotropic N-methyl-D-aspartate 3A (GRIN3A), with nicotine dependence in European- and African-American smokers.Semantic proximity Read ↗

Serotonin transporter and receptor genes significantly impact nicotine dependence through genetic interactions in both European American and African American smokers.Semantic proximity Read ↗

Dopamine genes and nicotine dependence in treatment-seeking and community smokers.Semantic proximity Read ↗

Novel genes identified in a high-density genome wide association study for nicotine dependence.Semantic proximity Read ↗

Detection of genetic association and a functional polymorphism of dynamin 1 gene with nicotine dependence in European and African Americans.Semantic proximity Read ↗

Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits.Semantic proximity Read ↗

Association Between CHRNA3 and CHRNA5 Nicotine Receptor Subunit Gene Variants and Nicotine Dependence in an Isolated Populationof Kashubians in Poland.Semantic proximity Read ↗

Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers.Semantic proximity Read ↗

Role of nicotine dependence in the association between the dopamine receptor gene DRD3 and major depressive disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.