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Article

Pharmacogenetics of nicotine addiction: role of dopamine.

Pharmacogenomics - 1 Feb 2014

Herman Aryeh I, DeVito Elise E, Jensen Kevin P, Sofuoglu Mehmet

Abstract excerpt

The neurotransmitter dopamine (DA) plays a central role in addictive disorders, including nicotine addiction. Specific DA-related gene variants have been studied to identify responsiveness to treatment for nicotine addiction. Genetic variants in DRD2, DRD4, ANKK1, DAT1, COMT and DBH genes show some promise in informing personalized prescribing of smoking cessation pharmacotherapies. However, many trials studying...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24444411
DOI: 10.2217/pgs.13.246
PMCID: PMC4154357

Genes

COMT
DBH
DRD2
DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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