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Article

Polymorphisms in HTR2A and DRD4 Predispose to Smoking and Smoking Quantity.

PloS one - 1 Jan 2017

Pérez-Rubio Gloria, Ramírez-Venegas Alejandra, Noé Díaz Valeri, García Gómez Leonor, Elvira Fabián Karina, García Carmona Salvador, López-Flores Luis A, Ambrocio-Ortiz Enrique, Contreras Romero Rocío, Alcantar-Ayala Noé, Sansores Raúl H, Falfán-Valencia Ramcés

Abstract excerpt

BACKGROUND: Genes encoding the receptors involved in the dopaminergic and serotonergic pathways are potential candidates in the mechanisms of nicotine addiction. AIMS: To identify genetic variants in the promoter regions and exons of the DRD4 and HTR2A genes associated with tobacco smoking and the degree of nicotine addiction in Mexican mestizos. METHODS: The study included 438 non-smokers (NS) and 1,157 current...

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Identifiers

PMID: 28103253
DOI: 10.1371/journal.pone.0170019
PMCID: PMC5245876

Genes

DRD4

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