Article
Significant association of DRD1 with nicotine dependence.
Human genetics - 1 Mar 2008
Huang Weihua, Ma Jennie Z, Payne Thomas J, Beuten Joke, Dupont Randolph T, Li Ming D
Abstract excerpt
Epidemiologic studies have strongly implicated genetics in smoking behavior. Genes in the dopaminergic system, which mediates the reinforcing and dependence-producing properties of nicotine, are plausible candidates for roles in nicotine dependence (ND). In this study, we examined five single-nucleotide polymorphisms (SNPs) within or near the dopamine D(1) receptor gene (DRD1) for their association with ND, which...
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