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Apolipoprotein E e4 and Cognitive Function: A Modifiable Association Results from Two Independent Cohort Studies.

Dementia and geriatric cognitive disorders - 1 Jan 2016

Perna Laura, Mons Ute, Rujescu Dan, Kliegel Matthias, Brenner Hermann

Abstract excerpt

BACKGROUND: The apolipoprotein E (APOE) e4 genetic polymorphism is a major risk factor for Alzheimer' s disease, hence the possible prevention of its detrimental effects on cognition is of high relevance. METHODS: We used linear regression models to assess associations of APOE e4 with cognitive performance in a population-based cohort study (n = 1,434) and in a cohort of patients with coronary heart disease (n =...

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Source

Identifiers

PMID: 26495840
DOI: 10.1159/000440697

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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