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Article

APOE4 and cognition in intracranial atherosclerosis: beyond Alzheimer's pathology.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2026

Cheng Anqi, Zou Yinxi, Liu Linwen, Wang Hebo, Ai Zhibing, Wu Shiwen, Si Qianqian, Liu Yiyang, Zhou Huanyu, Guo Haoyao, Yu Qiuyu, Wang Zijue, Li Mingli, Liu Caiyan, Xu Weihai

Abstract excerpt

INTRODUCTION: The apolipoprotein E ε4 (APOE ε4) allele is a major genetic risk factor for Alzheimer's disease, but its relevance to cognition in intracranial atherosclerosis (ICAS) remains unclear. We investigated the association between APOE ε4 and cognition in ICAS. METHODS: Baseline data from a multicenter cohort were analyzed. Patients with radiologically confirmed ICAS underwent APOE genotyping, plasma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41618438
DOI: 10.1002/alz.71087
PMCID: PMC12858425

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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