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Article

Genetic Alzheimer's Disease Risk Affects the Neural Mechanisms of Pattern Separation in Hippocampal Subfields.

Current biology : CB - 2 Nov 2020

Lee Hweeling, Stirnberg Rüdiger, Wu Sichu, Wang Xin, Stöcker Tony, Jung Sonja, Montag Christian, Axmacher Nikolai

Abstract excerpt

The hippocampal subfields perform distinct operations during acquisition, differentiation, and recollection of episodic memories, and deficits in pattern separation are among the first symptoms of Alzheimer's disease (AD). We investigated how hippocampal subfields contribute to pattern separation and how this is affected by Apolipoprotein-E (APOE), the strongest AD genetic risk factor. Using ultra-high-field (7T)...

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Identifiers

PMID: 32916120
DOI: 10.1016/j.cub.2020.08.042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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