Article

Functional neural signatures of navigation impairment in early Alzheimer’s Disease

2026-06-29

Abstract excerpt

Spatial navigation is impaired early in Alzheimer’s disease (AD), but the neural computations affected by AD pathology remain unclear. We combined virtual-reality navigation with fMRI in aged controls, preclinical AD, and early AD participants, relating navigation activity to cerebrospinal fluid biomarkers and genetic risk. Early AD was associated with dissociable alterations: amyloid- β -linked hippocampal hyper...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 25827559-e1d5-5a3e-95b9-64e3cb3e33e2
DOI: 10.64898/2026.06.24.734294

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Functional neural signatures of navigation impairment in early Alzheimer’s DiseaseDOI 10.64898/2026.06.24.734294Read

Functional connectivity between the entorhinal and posterior cingulate cortices associated with navigation impairment following path integration in at-genetic-risk Alzheimer’s diseaseSemantic proximity Read

Healthy versus Entorhinal Cortical Atrophy Identification in Asymptomatic APOE4 Carriers at Risk for Alzheimer's Disease.Semantic proximity Read

Reduced grid-cell–like representations in adults at genetic risk for Alzheimer’s diseaseSemantic proximity Read

Early detection of Alzheimer’s disease pathophysiology using 3D virtual reality navigation: a correlational study with genetic and plasma biomarkersSemantic proximity Read

Unmasking selective path integration deficits in Alzheimer’s disease risk carriersSemantic proximity Read

Frontal Functional Connectivity Impairment in Early Stages of Alzheimer’s DiseaseSemantic proximity Read

Functional connectivity between the entorhinal and posterior cingulate cortices underpins navigation discrepancies in at-risk Alzheimer's disease.Semantic proximity Read

No effects of APOE ε4 on spatial navigation and broader cognition in young adults genetically at risk for Alzheimer’s diseaseSemantic proximity Read

Test-retest reliability of spatial navigation in adults at-risk of Alzheimer's disease.Semantic proximity Read

Impact of Sex and <i>APOE</i> Status on Spatial Navigation in Pre-symptomatic Alzheimer’s diseaseSemantic proximity Read

Allocentric and Egocentric Spatial Processing in Middle-Aged Adults at High Risk of Late-Onset Alzheimer's Disease: The PREVENT Dementia Study.Semantic proximity Read

The effect of APOE genotype and streamline density volume, on hippocampal CA1 down-regulation: a real-time fMRI virtual reality neurofeedback studySemantic proximity Read