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Article

Functional connectivity between the entorhinal and posterior cingulate cortices underpins navigation discrepancies in at-risk Alzheimer's disease.

Neurobiology of aging - 1 Jun 2020

Coughlan Gillian, Zhukovsky Peter, Puthusseryppady Vaisakh, Gillings Rachel, Minihane Anne-Marie, Cameron Donnie, Hornberger Michael

Abstract excerpt

Navigation processes that are selectively mediated by functional activity in the entorhinal cortex may be a marker of preclinical Alzheimer's disease (AD). Here, we tested if a short path integration paradigm can detect the strongest genetic-risk phenotype of AD in large sample of apolipoprotein E (APOE)-genotyped individuals. We also examined the associations between APOE-mediated navigation process, subjective...

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Identifiers

PMID: 32171591
DOI: 10.1016/j.neurobiolaging.2020.02.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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