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Article

Evidence of Selection against Complex Mitotic-Origin Aneuploidy during Preimplantation Development

22 Oct 2015

Abstract excerpt

Whole-chromosome imbalances affect over half of early human embryos and are the leading cause of pregnancy loss. While these errors frequently arise in oocyte meiosis, many such whole-chromosome abnormalities affecting cleavage-stage embryos are the result of chromosome missegregation occurring during the initial mitotic cell divisions. The first wave of zygotic genome activation at the 4-8 cell stage results in...

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Share to Genomic variations and chromosomal abnormalities
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PMID: 26491874
DOI: 10.1371/journal.pgen.1005601

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