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Preimplantation embryos that arrest in vitro: phenotypes, causes, and possible therapies.

Fertility and sterility - 1 Aug 2026

Cimadomo Danilo, Isernia Margherita, Summers Michael C, Currie Cerys E, Rienzi Laura, Ottolini Christian Simon

Abstract excerpt

This review examines the biological basis of human preimplantation embryo developmental arrest, a major limiting factor in reproductive success both in vivo and in vitro. It integrates morphological, genetic, and environmental evidence to hypothesize the origins and consequences of early embryonic failure. Abnormal cleavage-stage phenotypes, including multinucleation, atypical division patterns, and...

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PMID: 42252047
DOI: 10.1016/j.fertnstert.2026.06.003

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