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Meiotic and mitotic aneuploidies drive arrest of in vitro fertilized human preimplantation embryos

1 Oct 2023

Abstract excerpt

BACKGROUND: The high incidence of aneuploidy in early human development, arising either from errors in meiosis or postzygotic mitosis, is the primary cause of pregnancy loss, miscarriage, and stillbirth following natural conception as well as in vitro fertilization (IVF). Preimplantation genetic testing for aneuploidy (PGT-A) has confirmed the prevalence of meiotic and mitotic aneuploidies among blastocyst-stage...

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PMID: 37779206
DOI: 10.1186/s13073-023-01231-1

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